Chronic immune thrombocytopenic purpura—who needs medication?
نویسندگان
چکیده
منابع مشابه
Chronic immune thrombocytopenic purpura. New agents.
First generation thrombopoietic growth factors (rhTPO and PEG-rHuMGDF), investigated in the early 2000s, proved effective in increasing platelet count in normal volunteers, in thrombocytopenia due to chemotherapy and also in a few cases of immune thrombocytopenic purpura (ITP). These agents did not complete their clinical development since one of them induced antibodies in the recipients that c...
متن کاملUpdate on chronic immune thrombocytopenic purpura (ITP)
Platelet production and circulation Thrombopoietin (TPO), the major cytokine affecting all phases of platelet production, is produced primarily by the liver and binds to the c-Mpl receptor located on platelets, stem cells and megakaryocytes. Upon stimulation, pluripotential stem cells produce cells committed to megakaryocyte differentiation. These cells initially undergo mitosis followed eventu...
متن کاملAcute Immune Thrombocytopenic Purpura in Infants
Abstract Objective Immune thrombocytopenic purpura (ITP) manifests as an easy bruising or extravasation of blood from capillaries into skin and mucous membranes. The characteristics of acute ITP in infants have rarely been described. In order to better understand acute ITP in infants, the characteristics of the disease at this age group was investigated. Material and Methods The present des...
متن کاملSpontaneous intracranial haemorrhage in children with chronic immune thrombocytopenic purpura.
Spontaneous intracranial haemorrhage (ICH) is a rare complication of chronic immune thrombocytopenic purpura (ITP) in children. We report four patients with cITP who developed ICH. The latency between onset of ITP and ICH varied from 1-8 years. All our patients were profoundly thrombocytopenic (platelet count of <10 x 109/l) at the time of their intracranial bleed. The presenting features and m...
متن کاملImmunomodulatory treatments for persistent and chronic immune thrombocytopenic purpura
BACKGROUND Corticosteroid sparing is required in 15% to 40% of adults with persistent or chronic primary immune thrombocytopenic purpura (ITP). Herein, the efficacy of immunomodulatory drugs (dapsone, interferon alpha, danazol, and hydroxychloroquine as second-third-line therapies in ITP is investigated. METHODS MEDLINE was searched for studies that included patients with persistent or chroni...
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ژورنال
عنوان ژورنال: Annals of Hematology
سال: 2010
ISSN: 0939-5555,1432-0584
DOI: 10.1007/s00277-010-0918-0